Enjoy Van Nuys, CA Hotel's Proximity to LA Attractions If you're searching for premium business or vacation lodging near Los Angeles, look no further than the Holiday Inn Express Van Nuys hotel. We are a short, 20-minute drive from downtown LA and ideally situated just off of the 405-freeway. The combination of this top location, a helpful, multilingual staff and amenities that offer all the comfort and conveniences of home make for a memorable stay in the Los Angeles area. The hotel's business guests can make a circuit of major area corporations like Anheuser-Busch and Capital Records, and members of the medical industry find Kaiser Permanente and Northridge Hospital within easy driving distance. If you prefer to conduct business meetings on-site, consider booking one of our three conference rooms. This lodging is also near timeless Los Angeles attractions like Universal Studios, the Staples Center and, of course, Hollywood and Beverly Hills.